THE OMICRON VARIANT BREAKS THE EVOLUTIONARY LINEAGE OF SARS-COV2 VARIANTS
Jean Claude Perez1, Valère Lounnas2, Pr Luc Montagnier1 PhD Maths and Computer Science Bordeaux University; Retired (IBM European Research center on Artificial Intelligence Montpellier France); Bordeaux metropole, France. 2 PhD; EMBL Heidelberg alumni, Meyerhofstraße 1, 69117 Heidelberg, Germany. 3Fondation Luc Montagnier Quai Gustave-Ador 62 1207 Genève, Switzerland.Received 4 November 2021Accepted 15 December 2021Published 31 December 2021Corresponding AuthorJean Claude Perez, jeanclaudepere2@gmail.comDOI 10.29121/granthaalayah.v9.i12.2021.4418 Funding: This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.Copyright: © 2021 The Author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ABSTRACTWe analyzed 15 genomes and Spikes of the new OMICRON variant, on the one hand 7 from the very first 21K lineage (South Africa, USA, Belgium, Canada), on the other hand 8 from the later second sister-clade 21L (USA, Switzerland, UK). We applied, at the scale of the whole genome and the spike gene, the biomathematics method of Fibonacci meta-structure fractal analysis applied to the UA / CG proportions.There appears a total rupture of this variant with respect to all the previous variants, and a strong differentiation between these 2 OMICRON lines.We have evidenced the RUPTURE of OMICRON with respect to ALL the previous variants: D614G, ALPHA, BETA, GAMMA, DELTA. In particular, we suggest that the mRNA stabilizing secondary structure ("hairpin" conformation) in the spike of all variants is degraded in OMICRON, probably making its mRNA more fragile.The loss of long-range fractal meta-structures in the OMICRON spike gene are in line with common knowledge on the mechanisms of epidemic ending, involving recombination of heavily mutated RNA fragments of the virus, with the possible inference of a distinct helper virus. This would indicate that the SARS-CoV2 is under very strong evolutionary pressure, possibly marking the end of the pandemic.Remarkably, it is observed that the density of OMICRON mutations in the SPIKE PRION region is more than 8 times that of the rest of the Spike protein. This high density of mutations of the Prion region in OMICRON appears to completely suppress this possible Prion function, unlike the Spikes of the various variants and mRNAs vaccines where this Prion function is observed.Keywords: Covid-19, SARS-CoV-2, Epidemic Ending, Variant Omicron, Collective Immunity, Genome Order, Fractal Metastructures, Prion Protein Function, Fibonacci"Science doesn't tell us where we're going - that's the role of art -; it tells us where we are." Alan TURINGADDENDUM by Pr Luc Montagnier"A big step towards understanding Nature. Your work gives us hope that we will soon emerge from the nightmare where the Cretinoid branch of Humanity plunges us" Luc Montagnier
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